Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Does plaquenil compromise the immune system Plaquenil knee side effects Stevens Johnson Syndrome and its more severe form, toxic epidermal necrolysis, are serious allergic reactions to medications. They can arise at any time, even if the medication has previously been. Stevens-Johnson syndrome requires hospitalization, often in an intensive care unit or a burn unit. Stopping nonessential medications The first and most important step in treating Stevens-Johnson syndrome is to discontinue any medications that may be causing it. Stevens-Johnson syndrome erythema multiforme is an acute inflammatory polymorphic disease affecting skin and mucous membranes. All ages may be affected, and the incidence is equal in both sexes. This is a severe disease with a 5%–15% mortality rate. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil steven johnson syndrome Which Drugs Are Most Associated With Stevens-Johnson Syndrome., Stevens-Johnson syndrome - Diagnosis and treatment - Mayo Clinic Plaquenil and weight gain Stevens-Johnson syndrome was named after two American pediatricians in 1922, Albert Stevens and Frank Johnson. They made a published description of the disorder in an American journal about two boys who had generalized skin eruptions with continuous fever, severe purulent conjunctivitis and inflamed oral mucosa. Stevens-Johnson Syndrome - Pictures, Symptoms, Causes, Diagnosis. Stevens-Johnson Syndrome. Hydroxychloroquine Plaquenil RheumTutor. Stevens-Johnson syndrome SJS is a rare and serious condition of your skin and mucus membranes. SJS will cause you to lose up to 10% of your outer layer of skin. SJS is usually caused by a response to a medicine you have been taking. It is unclear how often Stevens-Johnson syndrome or other rashes occurs with chloroquine use. Although there have been several reported cases of both adults and children developing these rashes while using chloroquine, no studies have looked at how often this actually happens. Plaquenil Related Stevens-johnson syndrome seen in social media and in the FDA adverse event database.