I did stop it for 2 weeks early in the treatment due to having to take a coupld other drugs that seemed to give me side effects. I just quit the plaquenil to give my liver a rest at that time. Plaquenil isn a antiparasitic drug with anti-inflammatory affect. What happens if you double doses of plaquenil What does plaquenil do to the immune system Aug 28, 2012 Plaquenil hydroxychloroquine takes a long time to get out of the system - up to 18 months. Be certain you and your physician agree you should discontinue it. HealthTap does not provide medical advice, diagnosis, or treatment. For these services, please use HealthTap Prime or Concierge. See Additional Information. Aug 27, 2010 Plaquenil is one of those meds you can just stop. My rheumy told me to take a months rest from it once. I asked him about 'tapering' and he said "No - just stop it - and resume after a month." Withdrawal syndrome is found among people who take Plaquenil, especially for people who are female, 50-59 old also take medication Lyrica, and have Fibromyalgia. This study is created by eHealthMe based on reports of 48,911 people who have side effects when taking Plaquenil from Food and Drug Administration FDA, and is updated regularly. Over the years on this site we have had quite a few people post that they didn't think that the plaquenil was working so they would stop taking it. I have done a lot of research on this drug and haven't run into anybody who has complained of the withdrawal effect. Stopping plaquenil suddenly Hydroxychloroquine - Side Effects, Dosage, Interactions., Can you just stop taking plaquenil or do you have to wean off. Hydroxychloroquine alternativeHydroxychloroquine mode of actionHydroxychloroquine brand name Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up. What is the correct way to discontinue use of plaquenil?. Will you have Withdrawal syndrome with Plaquenil - eHealthMe. Side effects to Stopping Plaquenil. - Sarcoidosis - Inspire. I have read about people stopping P & flaring up. Those who stopped it abruptly had real problems similar to what you are experiencing. If you really need to get off it, I would taper down slowly, very slowly. There is a similar posting on Healthunlocked, "Why oh why did u stop taking plaquenil." You may want to check it out. Here are 10 things to keep in mind when using Plaquenil Take it on a regular schedule, meaning at the same time each day. Take Plaquenil EXACTLY as prescribed by your physician. Do not stop taking the medication without first speaking to your doctor. Taking Hydroxychloroquine with food and/or. If your ophthalmologist does find some Plaquenil deposits, s/he will simply request that you stop taking the medication, and you may follow up with your rheumatologist about another advised method of treatment. Unfortunately, retinal damage caused by Aralen may be irreversible, but this medication is rarely prescribed anymore for lupus.