This eye toxicity limits long-term use of the drugs. The risk of toxicity is low for individuals without complicating conditions during the first 5 years of treatment using less than 6.5 mg/kg/day of hydroxychloroquine or 3 mg/kg/day of chloroquine, and/or cumulative doses of less than 1000 gram and 460 gram (total dose), respectively. Chloroquine prep Hydroxychloroquine sulfate tablets usp 200 mg uses Chloroquine resistance map Plaquenil and creatinine IMPORTANCE Hydroxychloroquine sulfate is widely used for the long-term treatment of autoimmune conditions but can cause irreversible toxic retinopathy. Prior estimations of risk were low but were based largely on short-term users or severe retinal toxicity bull's eye maculopathy. Hydroxychloroquine, sold under the brand name Plaquenil Sanofi-Aventis, is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. 1 By some estimates, more than 150,000 patients are on long-term therapy with this medication in America alone. 2 Retinal toxicity associated with HCQ use is. Published April 20, 2011 New Plaquenil Guidelines Here is a look at the 2011 testing guidelines for patients on Plaquenil guidelines. Diana L. Shechtman, O. D. and Paul M. Karpecki, O. D. The earliest signs of toxicity include bilateral paracentral visual field changes (best detected with a red test object) and a subtle granular depigmentation of the paracentral RPE. Some physicians suggest that lean body weight is more accurate when calculating daily dosage. Plaquenil retinopathy Retinal Physician - Hydroxychloroquine Maculopathy An., Multimodal Imaging in Plaquenil Toxicity Can you take diet pills with hydroxychloroquineCan you gain weight on plaquenilImuran and plaquenil tHydroxychloroquine to stop flare ups Abstract Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Recommendations on Screening for Chloroquine and.. New Plaquenil Guidelines. Hydroxychloroquine toxicity - EyeWiki. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a ppatient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity. We don’t know which patients might develop Plaquenil retinopathy, but the patient often can see it before the doctor can,” he says. Here are some important warning signs “If you feel like your central vision is getting blurred, if you lose the ability to see a digital clock, if you lose color vision—if reds look kind of washed out.