Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. When do you use hydroxychloroquine in rheumatoid arthritis Taking methotrexate and plaquenil together Can i take antacids while taking plaquenil Chloroquine phosphate 250 mg oral tablet People with retinal damage from Plaquenil are not aware at first that they are losing vision. Unfortunately, once they lose a severe amount of vision loss, it is permanent. If you take Plaquenil, it is very important to see an ophthalmologist regularly. Your ophthalmologist will check your retina for problems before serious damage occurs. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of hydroxychloroquine, if you use hydroxychloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Call your doctor right away if you have any eyesight. Download PDF. Drug-induced ocular side effects are back in the spotlight, thanks to the Academy’s revision of its recommendations on screening for retinal toxicity from chloroquine and its analogue hydroxychloroquine Plaquenil. 1 There are hundreds of drugs with potential retinal toxicity—so many that the National Registry of Drug-Induced Ocular Side Effects doesn’t stratify them by. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Omphthamologists risks of hydroxychloroquine Drug spotlight on hydroxychloroquine Lupus Foundation of., Hydroxychloroquine Indications, Side Effects, Warnings. Lupus therapy allergy to plaquenilIs chloroquine an effective antimalarial drug in brazil At recommended doses, the risk of toxicity up to 5 years is under 1% and up to 10 years is under 2%, but it rises to almost 20% after 20 years. However, even after 20 years, a patient without toxicity has only a 4% risk of converting in the subsequent year. MAJOR RISK FACTORS High dose and long duration of use are the most significant risks. Recommendations on Screening for Chloroquine and Hydroxychloroquine.. Rx Side Effects New Plaquenil Guidelines and More.. Hydroxychloroquine toxicity - EyeWiki. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. The risk may be much higher because retinopathy can be detected earlier when using more sensitive screening techniques. OBJECTIVES To reassess the prevalence of and risk factors for hydroxychloroquine retinal toxicity and to determine dosage levels that facilitate safe use of the drug. Hydroxychloroquine is a commonly used medication for rheumatoid arthritis, systemic lupus erythematosus, discoid lupus, Sjögren syndrome, juvenile idiopathic arthritis, other mixed connective tissue autoimmune conditions, non-small cell lung cancer, and graft-versus-host disease GVHD, to name a few.