Age or sun spots arise when melanin, the pigment in the skin that deepens with tanning, accumulates in one area. Dark spots take years to develop, and once in place must either be covered cosmetically or bleached. Plaquenil dosage for arthritis Chloroquine dosage adult Plaquenil eye oct Is plaquenil a tnf How to Fight Dark Spots on Your Skin. That's why the most effective treatment for uneven skin tone might be patience. Under Cover. stand in a spot out of direct sunlight -- even little. Weird Things That Happen to Your Skin as You Age. Also called liver spots, these small dark patches often show up in places that get lots of sun, like your face, hands, shoulders, and arms. My dermatologist gave me the reason, when asked, why my skin was turning a dark gray. I was really kind of worried, she replied "Side effect of the Plaquenil". I have been on plaquenil at least 12 years. It was a gradual change that I first thought was just dead skin that needed the loofa. Needless to say that made dry skin worse, so don't. However, if you decide to cover the spots instead, the process requires some basic makeup products and a little time. Use a liquid product close to the same shade as your skin color. Foundation is meant to even out the overall color of your skin. Chemical bleaching may lighten the spot, at least temporarily. Dark spots covering face from plaquenil PATIENT FACT SHEET Hydroxychloroquine Plaquenil, Weird Things That Happen to Your Skin as You Age Hydroxychloroquine sulfate adverse reactionsHydroxychloroquine sulfate and prednisone togetherChloroquine hair loss Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. Skin Discoloration and Plaquenil - Arthritis Information. Plaquinel changes hair color?" Lupus Community - Support.. Plaquenil Indications, Side Effects, Warnings -. Dark spots on your face come from aging and sun exposure. Age or sun spots arise when melanin, the pigment in the skin that deepens with tanning, accumulates in one area. Dark spots take years to develop, and once in place must either be covered cosmetically or bleached. Chemical bleaching may lighten the spot, at least temporarily. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. White pigment turns dark spots gray rather than fully concealing them, so your concealer needs to be roughly as dark as whatever you’re trying to cover up. Most people need, at most, two concealer shades an orange-based color for blue or purple shadows and a yellow-based one for redness.