Additionally, another exception occurred while executing the custom error page for the first exception. Chloroquine retinopathy, is a form of toxic retinopathy (damage of the retina) caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. Hydroxy chloroquine rheumatoid arthritis side effects Plaquenil dosage forms Malarone versus chloroquine Chloroquine phosphate has also been recommended in the treatment algorithm of Upper respiratory tract infection and pneumonia caused by COVID-19 infection Wuhan Coronavirus infection. In COVID-19 infection Wuhan Coronavirus infection, it is given with either oseltamivir or Darunavir. See chloroquine doses below. Adult dose Doses ≥ 5 mg/kg/day real weight of hydroxychloroquine 2.3 mg/kg/day of chloroquine are associated with higher risk of toxicity. Doses lower than 5 mg/kg/day have low risk 1% for the first 5 years, and below 2% between 5-10 years of use. The longer you use the medication, the higher the risk of toxicity. This represents a total dose of 2.5 g chloroquine phosphate or 1.5 g base in three days. The dosage for adults of low body weight and for infants and children should be determined as follows First dose 10 mg base per kg but not exceeding a single dose of 600 mg base. The risk of toxicity is low for individuals without complicating conditions during the first 5 years of treatment using less than 6.5 mg/kg/day of hydroxychloroquine or 3 mg/kg/day of chloroquine, and/or cumulative doses of less than 1000 gram and 460 gram (total dose), respectively. This eye toxicity limits long-term use of the drugs. Toxic dose of chloroquine Chloroquine DermNet NZ, Hydroxychloroquine And Chloroquine Screening 2016 AAO Recommendations. Can hydroxychloroquine cause diarrheaPlaquenil 200 mg and pregnancyPlaquenil and celebrex interactionCan i take claritin with plaquenil The dosage of chloroquine usually ranges between 100 and 500 mg/day. Side effects are minimal at low doses, while many more toxic effects occur at higher doses, such as visual disturbances, gastrointestinal upset, electrocardiographic changes, headache, and pruritus. Chloroquine in Cancer Therapy A Double-Edged Sword of Autophagy.. Aralen Chloroquine Uses, Dosage, Side Effects.. Chloroquine Dosage Guide with Precautions -. How to use Chloroquine Phosphate. Take this medication by mouth, usually with food to prevent stomach upset, exactly as directed by your doctor. Daily or weekly dosing, dosage amount, and length. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Some advocate high-dose diazepam e.g. 2 mg/kg over 30 min, followed by 1-2 mg/kg/day for 2-4 days post-intubation in the patient with severe chloroquine toxicity. This stems from the French experience e.g. Riou et al, 1988 which suggests much improved mortality in patients receiving high dose diazepam.