B, Brown pigmentation on the legs in another patient who had systemic lupus erythematosus associated with diffuse discoid lupus. The skin biopsy was performed on the brown area distant from discoid lesions. Hydroxychloroquine sulfate 200 mg cost Plaquenil for hashimoto's To analyze the risk factors for toxic effects, we performed a case-control study comparing these 24 patients with SLE with 517 patients with SLE in the PLUS Plaquenil LUpus Systemic Study who were treated with HCQ and did not have HCQ-induced pigmentation PLUS Study Identifier NCT00413361. Drug-induced nail changes can perplex even expert dermatologists, however. Most drug-induced nail changes occur when a drug affects the nail epithelia, but drugs can also affect the nail matrix, the nail bed, or the periungual tissue. Drug-induced changes may accumulate in, and discolor, the nail or surrounding skin. Certain medications change digital perfusion, leading to necrosis or blood vessel damage. Lichen planus thins the nail plate, which may become grooved and ridged. The nail may darken, thicken or lift off the nail bed onycholysis. Sometimes the cuticle is destroyed and forms a scar pterygium. The nails may shed or stop growing altogether, and they may rarely, completely disappear anonychia. B, Presence of iron in the same areas of the dermis (Perls staining, original magnification ×100). Pub Med Google Scholar Crossref Morrison LK, Nordlund JJ, Heffernan MP. Pub Med Google Scholar Costedoat-Chalumeau N, Galicier L, Aumaître O, et al; Group PLUS. Google Scholar Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Pub Med Google Scholar Crossref Costedoat-Chalumeau N, Leroux G, Piette J-C, Amoura Z. A, Interstitial and perivascular brown pigmented granules in the dermis (hematoxylin-eosin-safran staining, original magnification ×100). Plaquenil nail changes Lichen Planus in Adults Condition, Treatments, and., Drug-Induced Nail Changes Counting to 10 Plaquenil skin pigmentHydroxychloroquine prevent miscarriageGi problems with hydroxychloroquine Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Plaquenil Side Effects Common, Severe, Long Term -. Lichen planus DermNet NZ. Nail Abnormalities Symptoms, Causes, and Prevention. Answer. Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. This is a late finding, however, and too late for screening to be useful. RARE side effects. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells.