The proposed mechanism is inhibition of CYP450 2D6 hepatic metabolism by hydroxychloroquine. In a randomized, double-blind, crossover study, seven healthy subjects with CYP450 2D6 extensive metabolizer phenotypes took 400 mg hydroxychloroquine or placebo twice daily for 8 days, and 100 mg metoprolol orally on the ninth day. Plaquenil package insert Chloroquine and ciprofloxacin for typhoid prophylaxis Rash from taking plaquenil Chloroquine autophagy lc3 Combining metoprolol tartrate with digoxin may cause a dangerously slow heart rate bradycardia. You may need to be monitored very closely if you take these medications together. In some cases, it is not recommended to combine metoprolol tartrate with digoxin. Like metoprolol tartrate, metoprolol succinate is used to treat high blood pressure and chest pain related to heart disease. It’s also used to treat heart failure. However, metoprolol succinate shouldn’t be used to prevent heart attacks. Metoprolol is a beta blocker and Lisinopril is an ace inhibitor. In fact, they are commonly used together in heart disease patients. Doctors give trusted answers on uses, effects, side-effects, and cautions Dr. Demarco on can i take metoprolol with losartan These are two different classes of medications used for treatment of high blood pressure and heart disease. No adverse effects were reported and the clinical significance is unknown. Average metoprolol AUC increased by 65% and maximum plasma concentrations increased by 72%. Can plaquenil and metoprolol tartrate be taken together Metoprolol tartrate and Plaquenil drug interactions - eHealthMe, Metoprolol Tartrate vs. Metoprolol Succinate A Comparison Methotrexate vs plaquenil for lupusIs there a generic form of plaquenil In a randomized, double-blind, crossover study, seven healthy subjects with CYP450 2D6 extensive metabolizer phenotypes took 400 mg hydroxychloroquine or placebo twice daily for 8 days, and 100 mg metoprolol orally on the ninth day. Average metoprolol AUC increased by 65% and maximum plasma concentrations increased by 72%. Does plaquenil have a negative effect on metoporol?. Can i take metoprolol with losartan - Answers on HealthTap. Metoprolol succinate and Plaquenil drug interactions.. Two of the most commonly used cardioselective beta-blockers are metoprolol and atenolol. Metoprolol is used for the management of angina pectoris, high blood pressure, irregular heart rhythm and prevention of heart attacks and heart failure. It is also said to be used for migraine headaches. Using metoprolol and diltiazem together may lead to increased side effects. This can cause fatigue, headache, fainting, swelling of the extremities, weight gain, shortness of breath, chest pain, decreased heartbeat/A – V block, or irregular heartbeat. If you take both medications together, tell your doctor if you have any of these symptoms. If you need 100mg of metoprolol a day then yes, it's fine. You can take up to 450mg of metoprolol per day, so it is within the dose range.