Hydroxychloroquine retinopathy prevalence

Discussion in 'Northwest Pharmaceuticals Canada' started by caffingenug, 16-Mar-2020.

  1. IG7 New Member

    Hydroxychloroquine retinopathy prevalence

    She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation.

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    Abstract Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. The incidence of HCQ retinopathy is very low. In fact, HCQ is estimated at having a 0.5% incidence of retinal toxicity after 5 years of therapy. 5, 6 Retinal toxicity secondary to HCQ is irreversible and can continue to progress following cessation of therapy. 7 Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1.

    Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use.

    Hydroxychloroquine retinopathy prevalence

    The Prevalence of Hydroxychloroquine Retinopathy and Toxic., Hydroxychloroquine retinopathy A review of imaging

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  3. The overall prevalence of HCQ retinopathy was 7.5%, but this increased to around 20% after 20 years of use for those taking 4.0–5.0 mg/kg ABW/day and can exceed 50% at 20 years for those taking.

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    This large retrospective study of hydroxychloroquine users found a prevalence of hydroxychloroquine retinopathy three times higher than previously reported, but the risk was highly dependent on dosage and duration of use. CONCLUSIONS AND RELEVANCE These data suggest that hydroxychloroquine retinopathy is more common than previously recognized, especially at high dosages and long duration of use. While no completely safe dosage is identified from this study, daily consumption of 5.0 mg/kg of real body weight or less is associated with a low risk for up to 10 years. Background/Purpose Hydroxychloroquine HCQ is a commonly used medication for SLE because of its highly favorable risk-benefit ratio. Drug-induced retinopathy is one of very few serious toxicities associated with long-term use. Studies have reported varied prevalence of HCQ retinopathy ranging from 0.5% to 7.5%.

  4. Mikrob XenForo Moderator

    Systemic lupus erythematosus predominantly affects women and is more common in blacks. Discoid Lupus Erythematosus Medication Antimalarial agents. Systemic Lupus Erythematosus SLE Symptoms, Signs. Chloroquine as alternative antimalarial in systemic lupus.
  5. bobster User

    Lupus causes widespread inflammation that usually involves your skin — particularly on your face and scalp. Hair loss w/ plaquenil temporary adjustment or permanent? Lupus Can it cause hair loss? - Mayo Clinic How to Prevent Hair Loss from Lupus 11 Steps with Pictures
  6. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus.

    Plaquenil - Side Effects, Uses, Dosage, Overdose.