Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine phosphate buy Does plaquenil keep you awake I'm 59 and suffered fot yrs. the fatigue is the worst and nothing makes it go away. For the severe joint pain, and I mean severe, I've been on prednisone 10 mg a day and plaquenil, but it's too early to tell if the plaquenil's working since it can take 4 to 6 months. With one dose of the prednisone the joint pain went away. Skin Hyperpigmentation with Hydroxychloroquine Hydroxychloroquine Plaquenil is a common trade name is an anti-inflammatory oral medication that is commonly used to treat many autoimmune diseases. In the hair clinic, we use it for diseases such as lichen planopilaris, frontal fibrosing alopecia, Oral tranexamic acid may cause side effects like nausea, diarrhea, and stomach issues. In rare cases, it can lead to anaphylaxis or vision problems. Melasma Home Remedies. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Does plaquenil cause melasma Plaquenil side effect hyperpigmentation, Skin Pigmentation with Hydroxychloroquine Plaquenil. Plaquenil rash wont go awayDosage hydroxychloroquine lupus The exact cause of melasma remains unknown. Experts believe that the dark patches in melasma could be triggered by several factors, including pregnancy, birth control pills, hormone replacement therapy HRT and progesterone, family history of melasma, race, and anti-seizure medications. Melasma Treatments, Signs, Causes, During Pregnancy. Tranexamic Acid Side Effects and Possible Drug Interactions. Will you have Skin hyperpigmentation with Plaquenil - eHealthMe. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. Melasma is a common skin condition. Causing brown to graybrown patches, melasma usually appears on the face. The cheeks, bridge of nose, forehead, chin, and upper lip are places where melasma is likely to form. Has anyone else with Lupus developed this? The "freckles" on my forehead and upper.