Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Reviews on plaquenil for rheumatoid arthritis Hydroxychloroquine effect on eyes Plaquenil dosage for sarcoidosis Most common side effects people have besides Stress and anxiety * Pain 534 people, 35.98%. Drug Ineffective 469 people, 31.60%. Nausea feeling of having an urge to vomit 435 people, 29.31%. Joint Pain 431 people, 29.04%. Fatigue feeling of tiredness 427 people, 28.77%. We study how severe was Withdrawal syndrome, when it was recovered, drug effectiveness, race, and more among people who take Plaquenil. This study is created by eHealthMe based on reports of 1,993 people who have side effects when taking Plaquenil from sources other than FDA, and is updated regularly. Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil side effects anxiety Hydroxychloroquine Oral Route Side Effects - Mayo Clinic, Withdrawal syndrome in Plaquenil how severe and when it was. Baseline labs required before starting plaquenilWhitepill with plaquenilPlaquenil localized scleroderma Severe depression and anxiety, overall itching, pain and stiffness increased instead of decreased First, my mother and sister took plaquenil for lupus with good effect, so I am not just disliking it for no good reason. I also suffer from disabling bipolar disorder. For 25 years, I have gotten hypomanic during spring. Very happy, never depressed. PLAQUENIL Side Effects, Reviews by Patients -. Plaquenil Oral Uses, Side Effects, Interactions.. Anxiety and Plaquenil Has anyone experienced mood.. However, in some people hydroxychloroquine can cause skin rashes, especially those made worse by sunlight. feeling sick nausea or indigestion. diarrhoea. headaches. bleaching of the hair or mild hair loss. tinnitus ringing in the ears visual problems. Common side effects Nausea and diarrhea This can often can be combatted by taking Plaquenil with food or milk. Dizziness Precautions with this side effect Do not drive, use machinery. Cramps. Headache. Dry skin. Loss of appetite. Jul 16, 2018 After several months off of plaquenil, I went back on it, deciding to stick with the 100 mg per day. I have always been very sensitive to meds. Again my fatigue improved and I began to be able to do more. But again- over several months time my anxiety, depression, and sense of distance from personal relationships began to worsen.