It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Chloroquine resistance countries Cyp2d6 and plaquenil Plaquenil drinking alcohol Hydroxychloroquine liquid The volume of distribution for chloroquine is so large because this lipophilic drug log P = 4.7 partitions into tissue fat; whereas digoxin log P = 0.85 large volume is attributed to its binding to muscle ATPases. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. It is also being used as an experimental treatment for SARS-CoV-2. Antimalarial Drugs. If your plans include travel to southern Africa or another part of the world where malaria is common, you might need medicine to protect yourself against the mosquito-borne disease. But be aware. If you have psoriasis, chloroquine Aralen and hydroxychloroquine Plaquenil can cause problems. For prolonged treatment of lupus or arthritis, adverse effects include the acute symptoms, plus altered eye pigmentation, acne, anaemia, bleaching of hair, blisters in mouth and eyes, blood disorders, convulsions, vision difficulties, diminished reflexes, emotional changes, excessive coloring of the skin, hearing loss, hives, itching, liver problems or liver failure, loss of hair, muscle paralysis, weakness or atrophy, nightmares, psoriasis, reading difficulties, tinnitus, skin inflammation and scaling, skin rash, vertigo, weight loss, and occasionally urinary incontinence. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. For short-term treatment of acute malaria, adverse effects can include abdominal cramps, diarrhea, heart problems, reduced appetite, headache, nausea and vomiting. Chloroquine and digoxin The effects of chloroquine and other weak bases on the., Hydroxychloroquine - Wikipedia Hydroxychloroquine 200 mg para que sirvePlaquenil eye screening guidelinesPlaquenil for hair loss treatmentHydroxychloroquine blood test Learn about drug interactions between digoxin oral and hydroxychloroquine oral and use the RxList drug interaction checker to check drug combinations. digoxin oral brand names and other generic formulations include Cardoxin Oral, Digitek Oral, Digox Oral, Lanoxicaps Oral, Lanoxin Oral. Digoxin oral and hydroxychloroquine oral Drug Interactions.. Drugs & Medications That Can Trigger Psoriasis Flare-Ups. Digoxin‐Hydroxychloroquine Interaction? - Leden - 1982.. Interaction between digoxin and the natural cinchona alkaloid quinidine is well documented. A possible interaction between digoxin and the semisynthetic cinchona derivative hydroxychloroquine is reported in this communication. Digoxin is derived from the leaves of a digitalis plant. Digoxin helps make the heart beat stronger and with a more regular rhythm. Digoxin is used to treat heart failure. Digoxin is also used to treat atrial fibrillation, a heart rhythm disorder of the atria the upper chambers of the heart that allow blood to flow into the heart. Important Information The combo of digoxin and propranolol is cardiotoxic, while diazepam and morphine should act as a anaestethics and analgesics, perhaps creating respiratory depression. It has been used with reported success on a large number of terminally ill patients.