The electrical activity of heart cells is controlled by a set of channels that pump minerals, such as sodium and potassium, in and out of cells. If you inherit genes that cause alterations in these channels, it can affect the action of heart cells. Plaquenil monitoring Plaquenil for rheumatoid arthritis reviews PLAQUENIL may prevent life-threatening complications. PLAQUENIL prolongs the QT interval. Ventricular arrhythmias and torsades de pointes have been reported in patients taking PLAQUENIL see OVERDOSAGE. Therefore, PLAQUENIL should not be administered with other drugs that have the potential to prolong the QT interval see DRUG INTERACTIONS. Page 4 of 26 PLAQUENIL is not recommended for use in patients with baseline QTc prolongation e.g. congenital or acquired Long QT Syndrome, second-or third-degree atrioventricular block. QT Interval prolongation Hydroxychloroquine has the potential to prolong the QTc interval in patients with specific risk factors. Hydroxychloroquine should be used with caution in patients with congenital or documented acquired QT prolongation and/or known risk factors for prolongation of the QT internal such as • advanced age, The electrical impulse then travels down to the lower chambers of the heart, called the ventricles, causing contraction of the ventricles' muscle cells. Normally, an electrical impulse starts in the sinus node, located in the upper chamber of the heart. Plaquenil qt interval Drugs That Prolong the QT Interval and/or Induce Torsades de., Plaquenil Hydroxychloroquine Sulfate Hydroxychloroquine and infertility Plaquenil prolongs the QT interval. Ventricular arrhythmias and torsades de pointes have been reported in patients taking Plaquenil. Plaquenil should not be administered with other drugs that have the potential to prolong the QT interval. • Plaquenil has been shown to cause severe hypoglycemia including loss of consciousness that could Plaquenil hydroxychloroquine – New Warnings. DATA SHEET 1 PRODUCT NAME 2 QUALITATIVE AND QUANTITATIVE.. Long QT Syndrome Guide Causes, Symptoms and Treatment Options. The Corrected QT Interval QTc adjusts the QT interval correctly for heart rate extremes. Drugs that prolong QT interval and other arrhythmogenic drugs PLAQUENIL prolongs the QT interval and should not be administered with other drugs that have the potential to induce cardiac arrhythmias. Also, there may be an increased risk of inducing ventricular arrhythmias if PLAQUENIL is used concomitantly with other arrhythmogenic drugs. We present a case of a syncopal episode resulting from significant QT interval prolongation in a patient on hydroxychloroquine for the treatment of systemic lupus erythematosus and end stage renal disease. The patient had been treated with hydroxychloroquine.