Chloroquine ineffective in exoerythrocytic

Discussion in 'Reliable Pharmacy' started by OlegK, 14-Mar-2020.

  1. jeorceceise XenForo Moderator

    Chloroquine ineffective in exoerythrocytic


    Previously referred to as “Resochin”, Chloroquine was first discovered in 1924 at Bayer laboratories. Its first use was initially ignored as it was found to be toxic to people.

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    Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat. For instance, while chloroquine and amodiaquin act to suppress clinical symptoms by destroying the erythrocytic stages, the slow-acting drug primaquine destroys the exoerythrocytic stages. Currently, the optimal chemotherapeutic regimen for treatment of malaria includes taking chloroquine for 3 days followed by a single dose of primaquine after. Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted.

    These trials showed that chloroquine eliminated malaria and was appropriate to be used as an antimalarial drug. Thus, it was not until World War II that the government of the United States sponsored the clinical trials of chloroquine as an antimalarial drug.

    Chloroquine ineffective in exoerythrocytic

    DailyMed - CHLOROQUINE PHOSPHATE tablet, Exoerythrocytic Stage - an overview ScienceDirect Topics

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  4. The EC90 value of chloroquine against the 2019-nCoV in Vero E6 cells was 6.90 μM, which can be clinically achievable as demonstrated in the plasma of rheumatoid arthritis patients who received 500 mg administration.

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    Chloroquine concentrates in the food vacuole up to 1000-fold. Chloroquine, exists in unprotonated form, CQ, monoprotonated form, CQ + and diprotonated form, CQ ++ form 13. Unprotonated form of chloroquine is membrane permeable and it freely diffuses into the red blood cell. It then continues to diffuse into the DV. A. Chloroquine is ineffective as oral therapy for P. vivax malaria WRONG b. Chloroquine is ineffective on the exoerythrocytic malaria tissue stages c. Chloroquine is only effective against P. vivax when combined with metronidazole d. The patient has a second previously occult malaria infection e. Oct 01, 2018 Chloroquine is not active against the gametocytes and the exoerythrocytic forms including the hypnozoite stage P. vivax and P. ovale of the Plasmodium parasites. In vitro studies with Chloroquine demonstrated that it is active against the trophozoites of Entamoeba histolytica.

     
  5. Weil New Member

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  6. Rooter Well-Known Member

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    Hydroxychloroquine Indications, Side Effects, Warnings.
     
  7. Learn_Up XenForo Moderator

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