Retinal toxicity from plaquenil 2019

Discussion in 'Reliable Pharmacy' started by serpenter, 05-Mar-2020.

  1. Edige Well-Known Member

    Retinal toxicity from plaquenil 2019


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Plaquenil Retinal Toxicity. Hydroxychloroquine or Plaquenil, which was originally an anti-malaria drug, is now commonly used to reduce inflammation in rheumatoid arthritis and lupus. Patients on long-term treatment can accumulate the drug in their retinas, which can cause loss of vision. Traditionally, patients were followed primarily using visual. Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy Retinal toxicity from chloroquine CQ and its analogue, hydroxychloroquine HCQ, has been recognized for many years. Chloroquine toxicity remains a problem in many parts of the world, but is seen less frequently in the United States where the drug largely has been. Retinal toxicity than ideal body weight and allows estimations of risk that are independent of body habitusMaintaining daily use at 5.0mg/kg or less would keep both the cumulative risk and annual risk of retinal toxicity low, especially for the first 10 years of use.” • Melles RB, Marmor MF. JAMA Ophthalmol. 2014. Toxicity Risk Daily Dose

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Retinal toxicity from plaquenil 2019

    Recommendations on Screening for Chloroquine and., Recommendations on Screening for Chloroquine and Hydroxychloroquine.

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  6. People weighing more than 135 lbs. will stay within the safety guidelines not more than 6.5mg/kg/day at 400mg per day but people under 135lbs. should probably only be taking 200 mg per day. Other risk factors for Hydroxychloroquine retinal toxicity include kidney or liver disease and obesity.

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    The side effect that is of greatest concern is retinal toxicity. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. In individuals of Asian descent, retinal toxicity may first be noticed outside the macula. In patients of Asian descent, it is recommended that visual field testing be performed in the central 24 degrees instead of the central 10 degrees. It is recommended that hydroxychloroquine be discontinued if ocular toxicity is suspected and Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1.

     
  7. tamoginform Moderator

    La AR genera inflamación en las articulaciones, calor, reducción en el rango de movimiento y dolor. Plaquenil Para qué Sirve? Dosis Precio Fórmula y Genérico Plaquenil Oral Uses, Side Effects, Interactions, Pictures. Embarazo y Enfermedades Reumáticas
     
  8. Freeb00ter Guest

    Plaquenil for Alopecia Areata, Alopecia Totalis - Full. Alopecia areata is an autoimmune condition resulting in hair loss and complete baldness alopecia totalis. Published evidence says that it is mediated by T-lymphocytes. Plaquenil is an anti-inflammatory drug approved by the FDA for malaria, lupus erythematosus, and rheumatoid arthritis.

    Plaquenil Oral Uses, Side Effects, Interactions, Pictures.
     
  9. legioner_ua New Member

    Plaquenil - FDA prescribing information, side effects and uses Rheumatoid Arthritis. The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect see CLINICAL PHARMACOLOGY. Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses.

    Hydroxychloroquine Plaquenil