It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Plaquenil back pain and headache Plaquenil alcohol Fang and hydroxychloroquine screening I can only tolerate one 200mg dose of plaquenil a day. I allergic to sulfa, and the full does causes my skin to break out in an itchy burning rash from scalp to toes, and everywhere in between. So, I do not have stomach issues, probably because of that. However, the methotrexate does cause some intestinal distress the following day. In the past few months I've been experiencing chronic indigestion, heartburn and stomach cramps. Dr says it isn't an ulcer, possibly a stomach virus. I'm wondering if it could be a reaction to Plaquenil. If so, this is a new symptom from a med I've been on for about 3 years. Does anyone else have stomach problems related to SLE and what kind? Plaquenil is an arthritis medication and an anti infectious agent. Uses Plaquenil is prescribed for Lupus, RA, Sjogren's Syndrome and Joint Pain and is mostly mentioned together with these indications. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Plaquenil and stomach issues Hydroxychloroquine and stomach problems - Sticky Blood-Hugh., Lupus and Stomach Upset" Lupus Community - Support Group Chloroquine intercalating Hi, I JUst wanted to let you know that Plaquenil, and other lupus meds can be rough on your stomach.so in the beginning than long term. My doctor reccomended that I eat 100 calories at. Plaquenil and stomach issues." Lupus Community.. Can Plaquenil cause Stomach Issues? - Treato. Stomach pain from using plaquenil Undiagnosed Abdominal.. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. What Are Side Effects of Plaquenil? Common side effects of Plaquenil include. nausea, vomiting, stomach pain or cramps, loss of appetite, weight loss, diarrhea, dizziness, spinning sensation, headache, According to Drugs.com, Plaquenil given for a long term can cause retinal disorders after a few months or years of daily use--especially if the dose exceeds 400mg per day. The risk of retinal damage increases at doses of 600mg to 700mg. I've kinda noticed the same thing but I have a lactose intolerance. It wasn't as severe as it was when I was a child until I started Plaquenil. When I started Plaquenil almost 2 months ago I assumed the GI issues were a side effect and it would eventually go away but it hasn't. I'm going to bring it up to my rheumy when I see him.