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Association aux inhibiteurs de la mono-amine oxydase (IMAO) non sélectifs, irréversibles (voir rubrique Interactions avec d'autres médicaments et autres formes d'interactions). Maladie hépatique entraînant une insuffisance hépatique (voir rubrique Propriétés pharmacocinétiques). Association à la fluvoxamine, à la ciprofloxacine ou à l'énoxacine (inhibiteurs puissants du CYP1A2), associations entraînant une augmentation des concentrations plasmatiques de duloxétine (voir rubrique Interactions avec d'autres médicaments et autres formes d'interactions). Insuffisance rénale sévère (clairance de la créatinine est contre-indiquée chez les patients présentant une hypertension artérielle non équilibrée qui pourrait les exposer à un risque potentiel de crise hypertensive (voir rubriques Mises en garde et précautions d'emploi et Effets indésirables).a. 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