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CNS: nervousness, insomnia, dizziness, light-headedness CV: vasomotor flushing EENT: visual disturbances GI: nausea; vomiting; abdominal discomfort, distention, and bloating GU: breast tenderness, ovarian enlargement, multiple pregnancies, birth defects in resulting pregnancies, ovarian hyperstimulation syndrome, uterine bleeding Instruct patient to immediately report signs and symptoms of ovarian hyperstimulation syndrome, including nausea, vomiting, diarrhea, abdominal or pelvic pain, and swelling in hands or legs. • Advise patient not to take drug if she is or may become pregnant. If ovulation doesn't occur, increase to 100 mg/day P. If patient doesn't respond after three courses, no further doses are recommended. Start next course of therapy as early as 30 days after previous course. 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