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Several medicines are available in the market and over the internet. cialis overdose symptoms Comes in tablet form and is either taken one time before you expect to have sexual activity, or at a lower dose, once daily. Common side effects include headache, indigestion, back pain, and facial flushing. ) reported a sudden decrease or loss of vision in one or both eyes. It is not possible to determine whether these events are related directly to these medicines, to other factors such as high blood pressure or diabetes, or to a combination of these. If you experience sudden decrease or loss of vision, stop taking PDE5 inhibitors, including . It is not possible to determine whether these events are related directly to the PDE5 inhibitors, to other diseases or medications, to other factors, or to a combination of factors. 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The active component of the medicine reversibly selectively inhibits the cycle guanosine monophosphate (c GMP) that is the specific phosphodiesterase type 5 (PDE5). The local release of NO is registered during the sexual stimulation, and at the same time the specific phosphodiesterase of type 5 activity inhibition leads to the cycle guanosine monophosphate level increase in the corpus cavernosum. Due to tadalafil the smooth muscle tonus decrease and the penile blood inflow increase take place that stimulate erection. Tadalafil does not influence the sexual stimulation. The effect of tadalafil on other phosphodiesterases is insignificant so Cialis does not affect the cardiovascular system, the liver function, skeletal muscle and other organs. Tadalafil does not change the qualitative characteristics of sperm, does not change the level of testosterone, follicle-stimulating and luteinizing hormone in the blood. 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