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    In 1986 Tretinoin made a splash in Europe, it appeared to be extremely effective against acne, and later it was found out that it is also effective against warts, scarring, effectively removes the skin stratum cornea, fights with senile wrinkles, with spots, which appeared as a result of a sunburn, Fordyce granule. Such a wide range of action emerges because Tretinoin makes the upper layer of the skin thinner or in other words, has the effect of peeling. MEGAPACK 50 ml Exp Date: 12.2019Tretinoin is a trans-retinoic acid form of vitamin A. It stimulates mitosis and turnover of follicular epithelial cells and reduce their cohesiveness. This facilitates extrusion of existing comedones and prevents formation of new comedone. It also exhibits thinning effect on the stratum corneum. In acute promyelocytic leukaemia, it induces cellular differentiation and decreases proliferations. A prescription acne cream appears to moderately reduce sun damage in older people, says new research. Tazarotene cream (marketed as Zorac in South Africa) is in the same Vitamin A family as Retin-A, another acne drug considered to be a potent wrinkle reliever. While the drug is used by people with sun damage, the study's authors say their research, which was funded by the makers of the cream, offers more proof of its value. Combatting sun damage "The cream was better than moisturiser alone for improving fine wrinkling and mottled pigmentation of the skin, in combination with protecting skin from the sun," says study co-author Dr Tania Phillips, a professor of dermatology at the Boston University School of Medicine. Sun damage to skin begins at the first exposure to sunlight and accumulates over a lifetime, says Dr Richard Glogau, a clinical professor of dermatology at the University of California at San Francisco. Ultraviolet light penetrates the skin and damages its internal structure by wreaking havoc on the DNA of cells, he explains. "The initial changes are a loss of 'glow,' change in pigmentation - freckles, splotchiness, brown or muddy tones - and damage to elastic and collagen fibres resulting in wrinkles and fine lines," he adds.

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